Chapter 20: Carboxylic Acid Derivatives. Nucleophilic Acyl Substitution |
Nucleophilic Acyl Substitution : Reactive Systems
Step 1: The nucleophile adds to the electrophilic C in the polar carbonyl group, electrons from the C=O move to the electronegative O creating the tetrahedral intermediate. |
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Step 2: The intermediate collapses, reforming the strong C=O bond results in the loss of the leaving group, leading to the new carbonyl containing system. |
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© Dr. Ian Hunt, Department of Chemistry |