Qu : The structure of EPOTHILONE A, a compound with
anticancer activity similar to Taxol is shown to the right.
(a) What is the hybridisation of the following C atoms
in Epothilone A ?
(b) Arrange the following bonds in Epothilone A in
order of decreasing length:
C14-C15
C15-C17 C17-C18
(c) What type of bonding MOLECULAR orbitals are involved
in the bonds between C3-C4 and C17-C18 ?
(d) What are the oxidation states of the following
C atoms in Epothilone A ?
(e) Identify any C-C σ bonds in Epithilone A that are not between a pair of sp3
hybridised C atoms.
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