Chapter 20: Carboxylic Acid Derivatives. NucleophilicAcylSubstitution

Reactions for Interconverting Carboxylic Acids Derivatives

Here is a table that summarises the methods for interconverting carboxylicacid derivatives.  The more important reactions in emphasised in bold,and the reactions of the parent carboxylic acids (chapter 19)in blue.
 
 

To make ->  From
	-	RCO2-	R'OH	H2O	R2NH	H2O, HO-
	-	-	R'OH	H2O	R2NH	H2O, HO-
	-	-	R'OH, heat H+ or B-	H2O, H3O+ heat	R2NH	H2O, HO- heat
	SOCl2    or PCl3	Heat, -H2O	R'OH, heat H+	-	R2NH heat	HO-
	-	-	-	H2O, H3O+ heat	-	H2O, HO- heat
	-	RCOCl	R'-Br or -I	H3O+	-	-

© Dr. Ian Hunt, Department of Chemistry