![Return to Contents](mol.gif) |
Chapter 20: Carboxylic
Acid Derivatives. NucleophilicAcyl Substitution |
![Ch 20 contents](book.gif) |
Interconversion Reactions
of Acyl Chlorides
![conversion of acyl chlorides to other carboxylic acid derivatives](rcoclrxn.gif) |
acid anhydrides |
esters |
acids |
amides |
Reaction type: Nucleophilic
Acyl Substitution
Summary
- Acyl chlorides are the most reactive
of the carboxylic acid derivativesand therefore can be readily converted into
all other carboxylic acid derivatives(see above).
- They are sufficiently reactive
that they react quite readily with coldwater and hydrolyse to the carboxylic
acid.
- The HCl by-product is usually
removed by adding a base such as pyridine,C6H5N, or
triethyl amine, Et3N.