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Substituent Effects(contd.)
The regioselectivity for further substitution of disubstituted benzenes can usually be predicted by looking at the cumulative effects of the substituents.
As a suggested method, look at each of the substituents,
label their directing effects, then indicate the sites where they would promote
reactivity with small arrows. Some issues that can arise are shown by
the following worked examples:
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© Dr. Ian Hunt, Department of Chemistry |  |