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Chapter 6: Acidity and Basicity

Ch 1 contents

Structural Factors affecting Acidity : Inductive effects

Impact : small.... ΔpKa approx. 2 or 3 units / effect e.g. consider CH2ClCO2H (pKa = ??) vs CH3CO2H (pKa = 5)

ACIDITY : Look for factors that stabilise the conjugate base...we do this by simply removing the H+:

 


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© Dr. Ian Hunt, Department of Chemistry University of Calgary