Chapter 21: Ester Enolates
Reactions of Active Methylene systems
There are 3 potentially important reactions of active methylenes (
what are active methylenes ?
)
Reaction with alkyl halides (
alkylation
)
Conjugate addition to
a,b
-unsaturated carbonyls (
Michael addition
)
Loss of CO
2
(
decarboxylation
)
Alkylation
Michael addition
Decarboxylation
©
Dr. Ian Hunt
, Department of Chemistry